I too am having problems with Bixie VMUpload Pro and IE8 - I admit that I have not tested in other version of IE, but this is a popular browser in it's own right so I'm hoping that the same solution will apply to IE 7 (I can live with IE6 users not getting any joy!)
My issue is exactly the same as crops315.
Everything works beautifully in FF, Opera, Safari and Chrome but IE simply refuses to complete the upload process. Specifically, the candy stripe progress bar does not appear, and then, upon what appears to be a silent completion of the process, no popup of the image appears, so I then tried to use the add to cart button to see what happened; I was informed that I had not selected a valid product variant in the Ajax add to cart pop-up.
This suggests to me that at some point in the module code IE is not allowing the trigger of the child attributes through properly. I also suspected that this may have been down to Javascript and some element of the DOM but IE offers no syntax errors to indicate this.
I am using Windows 7 Dell installed IE8 with Joomal 1.5.19 and VM1.1.5 (patched from 1.1.4) along with Bixie Upload 1.5.1.0.1 Pro.
The domain is here *DOMAIN REMOVED BY USER*
(added by edit)I must add that the clothing section is really the only section worth trying, I have been mainly testing using the Zoodie, which is the first product in that that category.(/added by edit)
The site looks like a bag of nails; while I sort out this problem there is little point in final styling!
Any pointers would be much appreciated, and although I can hold my own in php, xhtml and css, my Javascript conflict knowledge is limited
Best regards
David